An Experimental Infection Study of Dermally-Applied Infectious Necator Americanus Hookworm Larvae in Hookworm-Naïve Adults

An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious.

Primary Outcome Measures:

  1. To estimate the frequency of study product-related adverse events, graded by severity, for different doses of N. americanus Larval Inoculum.

The George Washington Vaccine Research Unit is seeking volunteers who are:

  1. Males or females between 18 and 45 years, inclusive.
  2. Good general health as determined by means of the screening procedure.
  3. Available for the duration of the trial (6 months).
  4. Willingness to participate in the study as evidenced by signing the informed consent document.

For more information see:


Baylor College of Medicine
Principal Investigator(s)
David Diemert, MD, FRCP(C)
Contact Phone Number
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